OI | Rare Diseases Clinical Research Network

Higher Levels of Collagen X with Lower Growth Velocity May Reflect Growth Plate Dysfunction in Osteogenesis Imperfecta Dakota Campbell Thu, 08/12/2021 - 09:43

Children with osteogenesis imperfecta (OI) may experience growth plate dysfunction, according to a recent study in the journal Bone. Researchers from the Brittle Bone Disorders Consortium (BBDC) found a higher ratio of collagen X (CXM) levels for growth velocity in children with OI, revealing new clues about how this disease may affect the growth plate.

Brittle Bone Disorders Consortium

BBDC

osteogenesis imperfecta

OI

New Research

Zoe Fang, an osteogenesis imperfecta (OI) patient, at an arcade

Exploring Oral Health-Related Quality of Life in Children with Osteogenesis Imperfecta

August 26, 2020

In a new study, researchers in the Rare Diseases Clinical Research Network’s Brittle Bone Disorders Consortium (BBD) surveyed adolescents with osteogenesis imperfecta (OI) to learn about their oral symptoms and how these affect their quality of life. Participants’ answers are clarifying the oral health needs of kids with OI and guiding future research for orthodontic interventions.

Brittle Bone Disorders Consortium

BBD

osteogenesis imperfecta

OI

Subscribe to OI

The Rare Diseases Clinical Research Network (RDCRN) is funded by the National Institutes of Health (NIH) and led by the National Center for Advancing Translational Sciences (NCATS) through its Office of Rare Diseases Research (ORDR). The RDCRN websites are hosted by the network’s Data Management and Coordinating Center at Cincinnati Children’s Hospital Medical Center, which is funded by NCATS and the National Institute of Neurological Disorders and Stroke (NINDS) under grant number TR002818.